Maribel Guerra Vallespi,Julio Raúl Fernández Massó,Alexis Musacchio Lasa,Jeovanis Gil Valdés,Osvaldo Reyes Acosta,Brizaida Maylin Oliva Argüelles
申请号：
US13700286
公开号：
US08729226B2
申请日:
2011.05.31
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
