GUERRA VALLESPI MARIBEL,MUSACCHIO LASA ALEXIS,REYES ACOSTA OSVALDO,FERNANDEZ MASSO JULIO RAUL,GIL VALDES JEOVANIS,OLIVA ARGUELLES BRIZAIDA MAYLIN
申请号：
ZA201208905
公开号：
ZA201208905B
申请日:
2012.11.26
申请国别(地区):
ZA
年份:
2013
代理人:
摘要：
This invention describes a method for treating cancer by increasing the nuclear localization of the COMMD1 protein, which is associated with decreasing or blocking the proliferation of the cancer cell. The invention is also related to the use of agents that increase nuclear localization of the COMMD1 protein, in the manufacture of a medicament for cancer therapy. These agents can be peptides or proteins, among other compounds. The invention is also related to the optimization of a peptide, coming from the sequence HARIKPTFRRLKWKKYKGKFW, to increase the nuclear localization of the protein COMMD, and thus, to increase the antitumor effect of this peptide.
