The Board of Regents of the University of Texas System;Elizabeth Therapeutics LLC
发明人:
Jerry Shay,Ilgen Mender,Kimberly Batten,Cynthia Lander
申请号：
US15467862
公开号：
US20180036331A1
申请日:
2017.03.23
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The described invention is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatment of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.
