The Board of Regents of the University of Texas System
发明人:
Jerry SHAY,Ilgen MENDER,Kimberly BATTEN
申请号：
US16450430
公开号：
US20190388453A1
申请日:
2019.06.24
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The described invention is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatement of cancer and other hyperproliferative diseases. The described compounds can be converted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.
