THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
发明人:
Shay Jerry W.,Gryaznov Sergei M.
申请号：
NZ71349814
公开号：
NZ713498A
申请日:
2014.04.08
申请国别(地区):
NZ
年份:
2017
代理人:
摘要：
The present disclosure is directed toward pharmaceutical compositions and methods of using 6-mercaptopurine ribosides and analogues thereof for the treatement of cancer and other hyperproliferative diseases. The described compounds can be convereted into telomere substrates in vivo and can be recognized by telomerase for incorporation into telomeres of telomerase active cells, leading to induction of cell death of the telomerase active cells.
