GROB, Jonathan E.,MAC SWEENEY, Aengus,DECHANTSREITER, Michael A.,MILTZ, Wolfgang,RANDL, Stefan,SEDRANI, Richard,SELLNER, Holger,SIROCKIN, Finton,VALEUR, Eric
申请号：
ES13733200
公开号：
ES2584702T3
申请日:
2013.06.19
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound according to formula I ** Formula ** or salt or stereoisomer thereof, wherein R1 is hydrogen or halogen R2 is C1-C4 alkyl； R3 is hydrogen, C1-C6 alkyl, C1-C4 alkoxy-C1-C4 alkyl or C1-C4 haloalkyl； R4 is halogen, cyano or hydrogen, in which at least one of R1 and R4 is not hydrogen； R5 is independently selected at each occurrence of hydrogen, C1-C6 alkyl, C1-C4 alkoxy-C1-C4 alkyl, phenyl and C3-C6 cycloalkyl； k is 0-3； R6 is CH2CHR7R8, or R6 is CH>； = CHR9, where R9 is C3-C6 cycloalkyl or phenyl optionally substituted with 0, 1 or 2 groups independently selected from halogen, C1-C4 alkyl, C1-C4 alkoxy, C1- haloalkyl C4 or cyano； or R6 is bicyclic heteroaryl having 1 or 2 ring heteroatoms independently selected from N, O or S, partially unsaturated carbocycle or partially unsaturated heterocycle having 1 or 2 ring heteroatoms independently selected from N, O or S, each of the which is optionally substituted with from 0 to 3 substituents independently selected from amino, halogen, cyano, hydroxyl, C1-C4 alkyl or C1-C4 alkoxy； or R6 is CH2 heterocycle having 4 to 7 ring atoms and 1 or 2 ring heteroatoms selected from N, O or S, which is optionally substituted with 0, 1 or 2 groups independently selected from phenyl, halogen and C1-C6 alkyl , or two substituents, taken in combination form a benzo ring optionally substituted with halogen； R7 is (CH2) pNR10R11 or C (O) NRA 2, in which RA is independently selected at each occurrence of hydrogen and C1-C4 alkyl, or NRA 2 taken in combination form a 4-6 membered azacycle； p is 0 or 1； R8 is C1-C6 alkyl, C3-C6 cycloalkyl； or R8 is phenyl optionally substituted with 0-2 R12； or R8 is a 5 or 6 membered heteroaryl having 1 or 2 ring heteroatoms selected from N, O and S and optionally substituted with 0-2 R13 groups； R10 is hydrogen or C1-C4 alkyl； R11 is hydrogen, C1-C6 alkyl or optionally substituted C1-C6 haloalkyl, in which the optional substituents are selected from C1-C4 alkoxy, C3-C6 cycloalkyl and 4-6 membered h
