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DERIVE HETEROCYCLIQUE PRESENTANT UN EFFET D'ACTIVATION DE L'AMPK
专利权人:
LTD.;SHIONOGI & CO.
发明人:
KOJIMA, EIICHI,HINATA, YU,WADA, TOSHIHIRO
申请号:
CA2965781
公开号:
CA2965781A1
申请日:
2015.10.27
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. (In formula (I): L represents NR2R3, SR7, SO2R8, a substituted or unsubstituted alkyl, or a substituted or unsubstituted alkenyl; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R3 represents a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R7 represents a hydrogen atom, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; R8 represents a hydrogen atom, a substituted or unsubstituted alkyl (but not an unsubstituted methyl or an unsubstituted ethyl), a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like; Y represents a substituted or unsubstituted alkyl (but not an unsubstituted methyl or an unsubstituted ethyl), a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, a substituted or unsubstituted aryl, or the like; Z represents CR6= or N=; R1 represents a hydrogen atom or a substituted or unsubstituted alkyl; and R4, R5, and R6 are each independently a hydrogen atom, a halogen, a hydroxyl, a cyano, a nitro, a carboxy, a substituted or unsubstituted alkyl, a substituted or unsubstituted alkenyl, a substituted or unsubstituted alkynyl, or the like.)
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