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HETEROCYCLIC DERIVATIVE HAVING AMPK-ACTIVATING ACTIVITY
专利权人:
发明人:
Eiichi KOJIMA,Yu HINATA,Toshihiro WADA
申请号:
US15522504
公开号:
US20170333398A1
申请日:
2015.10.27
申请国别(地区):
US
年份:
2017
代理人:
摘要:
A compound represented by formula:or its pharmaceutically acceptable salt,whereinL is NR2R3, SR7, SO2R8, substituted or unsubstituted alkyl, or substituted or unsubstituted alkenylR2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the likeR3 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the likeR7 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the likeR8 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like, provided that R8 is not unsubstituted methyl or trifluoromethylY is substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted aryl, or the like, provided that Y is not unsubstituted methyl or unsubstituted ethylZ is —CR6═, or —N═R1 is hydrogen, or substituted or unsubstituted alkylR4, R5 and R6 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, or the like.
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