DERIVE AZABENZIMIDAZOLE SUBSTITUE EN POSITION 5 PRESENTANT UNE ACTION D'ACTIVATION DE L'AMPK

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专利权人:

LTD.;SHIONOGI & CO.

发明人:

TAMURA, YUUSUKE,SASAKI, YOSHIKAZU

申请号：

CA3021951

公开号：

CA3021951A1

申请日:

2017.04.26

申请国别(地区):

CA

年份:

2017

代理人:

摘要：

Provided is a compound useful as an AMPK activator. A compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In formula (I): L represents -NR1-, =N-, -O-, -S-, -SO2-, -CR2R3- or =CR2-； the broken line represents the presence or absence of a bond； X represents -CR4R5- or -O-； Y represents optionally substituted heteroaryl or optionally substituted heterocyclyl； Z represents =CR6- or =N-； R1 represents hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R2 and R3 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R4 and R5 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R6 represents hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R7, R8 and R9 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； R10 and R11 independently represent hydrogen, halogen, hydroxy, cyano, nitro, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, etc.； and R12 represents hydrogen or optionally substituted alkyl.]

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