Abdu Adem,Shaikha S. Al Neyadi,Ibrahim M. Abdu,Alaa A. Salem,Naheed Amir
申请号：
US16560919
公开号：
US10702525B1
申请日:
2019.09.04
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The pyrimidine derivatives as anti-diabetic agents are chloropyrimidinyl derivatives having the general formula of compound 81, wherein R1 is —；N(CH3)CH2CH2OH (compound 81c) or —；N(H)CH2CH2OH (compound 81f) or the general formula of compound 82, wherein R2 is —；N(CH3)CH2CH2OH (compound 82c) or —；N(CH2CH2)2O (compound 82d), as follows:The derivatives may be used for treating diabetes in humans or animals and have demonstrated efficacy, specifically in treating type 2 diabetes. Two methods of synthesizing the pyrimidine derivatives are described herein. The method using microwaves (Method B) is a green method that can provide high yields in a short time and with high purity. The compounds act as GLP-1 receptor agonists and are more potent than conventional drugs. As such, the compounds may be used in lower doses, and, hence, have fewer side effects.
