CARROLL, Frank,THOMAS, James,NAVARRO, Hernan,MASCARELLA, S.,RUNYON, Scott,JIN, Chunyang,KORMOS, Chad
申请号：
ES12856118
公开号：
ES2631607T3
申请日:
2012.12.10
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound represented by the formula: ** Formula ** where W, X, Y and Z are each independently hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, O-C 1-6 alkyl, OH, F, CI, Br, CN, CF3, NO2, N3, SO2CH3, SO2CF3, SO2NH2, NR31R32, NHCOR33, NHCO2R34, CONR35R36, CH2 (CH2) nY2, CH2O2-C1-8 alkyl, CO2-C1-8 alkyl or C ( >； = NH) NR37R38； R31, R32, R33, R34, R35, R36, R37 and R38 are independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, CH2-aryl substituted with one more substituents OH, Br, CI, F, CN, CF3, NO2, N3, SO2CH3, SO2CF3, SO2NH2, C1-6 alkyl or CH2 (CH2) nY2 '； each Y2 is independently hydrogen, CF3, CO2R9, C1-8 alkyl, NR10R11, NHCOR12, NHCO2R12, CONR13R14, CH2OH, CH2OR8, COCH2R9, ** Formula ** each n is independently 0, 1, 2 or 3； each R8, R9, R10, R11, R12, R13 and R14 is independently hydrogen, C1-8 alkyl, CH2-aryl where the aryl group is substituted with one or more substituents OH, Br, CI, F, CN, CF3 , NO2, N3, SO2CH3, SO2CF3, SO2NH2, C1-6 alkyl or CH2 (CH2) nY2 '； Each Y1 is independently hydrogen, OH, Br, CI, F, CN, CF3, NO2, N3, SO2CH3, SO2CF3, SO2NH2, OR8, CO2R9, C1-6 alkyl, NR10R11, NHCOR12, NHCO2R12, CONR13R14 or CH2 (CH2 ) nY2, or two adjacent Y1 groups form a -O-CH2-O- or -O-CH2CH2-O- group； each Y2 'is, independently, hydrogen, CF3 or C1-6 alkyl； or a pharmaceutically acceptable salt thereof.Un compuesto representado por la fórmula: **Fórmula** donde W, X, Y y Z son cada uno independientemente hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, O-alquilo C1-6, OH, F, CI, Br, CN, CF3, NO2, N3, SO2CH3, SO2CF3, SO2NH2, NR31R32, NHCOR33, NHCO2R34, CONR35R36, CH2(CH2)nY2, CH2O2-alquilo C1-8, CO2-alquilo C1-8 o C(>；=NH)NR37R38； R31, R32, R33, R34, R35, R36, R37 y R38 son, independientemente, hidrógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, CH2-arilo sustituido con uno más sustituyentes OH, Br, CI, F, CN, CF3, NO2, N3, SO2CH3, SO2CF3, SO2NH2, alquilo C1-6 o CH2(CH2)nY2'； cada Y2 es, independientemente, hidrógeno, CF3, CO2R9, alquil
