DEATON, DAVID,MCFADYEN, ROBERT,NAVAS, FRANK,CALDWELL, RICHARD,SPEARING, PAUL
申请号：
ES06840218
公开号：
ES2374165T3
申请日:
2006.12.13
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
A compound of formula (I): wherein: a is 1, 2, 3, 4 or 5； each R1 is the same or different and is independently selected from the group consisting of halo, alkyl, alkenyl, -O-CF3, -OR6, -S (O) fR6, -NR6R7, -R5OR6, -R5S (O) fR6, - R5NR6R7 and cyano； b is 0, 1, 2 or 3； R2 is selected from the group consisting of alkyl, alkenyl, C3-6 cycloalkyl optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, haloalkyl, alkenyl, -OH, -O-alkyl, -NH2, -NH (alkyl), -N (alkyl) 2, -CN, -NO2 and -N3, C3-6 cycloalkenyl optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, haloalkyl, alkenyl, -OH, -O -alkyl, -NH2, - NH (alkyl), -N (alkyl) 2, - CN, -NO2 and -N3, -R5OR6, -R5NR6R7 and cyano； Y is -O-, -S- or -N (R8) -； R3 is -C (O) 2H, -C (O) NRaRb, -C (O) 2Rc or nitrile, tetrazol, 1,2,4-oxadiazolidin-3,5-diones, 3 (2H) -isoxazolones, 1, 2,4-oxadiazol-5 (2H) -onas, 3H-1,2,3,5-oxathiadiazol 2-oxides； R4 is H, halo, alkyl or haloalkyl； each R5 is the same or different and is independently selected from the group consisting of alkylene and alkenylene； each R6 and R7 are the same or different and each is independently selected from the group consisting of H, alkyl, alkenyl, C3-6 cycloalkyl optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, haloalkyl, alkenyl, -OH, -O-alkyl, -NH2, -NH (alkyl), -N (alkyl) 2, -CN, -NO2 and -N3, C3-6 cycloalkenyl optionally substituted with one or more substituents selected from the group consisting of halo, alkyl, haloalkyl, alkenyl, -OH, -O-alkyl, -NH2, -NH (alkyl), -N (alkyl) 2, -CN, -NO2 and -N3； and f is 0, 1 or 2； each R8 is the same or different and is independently H or alkyl； or a pharmaceutically acceptable salt or solvate thereof.Un compuesto de fórmula (I): en donde: a es 1, 2, 3, 4 o 5； cada R1 es igual o diferente y se selecciona independientemente del grupo que consiste en halo, alquilo, alquenilo, -
