An in-the-ear (ITE) physiological measurement device (2) includes a structure (4) formed for easy insertion into multiple shaped and sized ear canals. An inflatable balloon (6) surrounds an end portion of the structure (4) to be positioned in the ear. Optionally, a mushroom shaped tip (22) is connected with an end of the structure (4) and carries a plurality of sensors (8). Inflation of the balloon (6) expands the tip (22) radially to position the sensors (8) proximate to vascular tissue within the ear canal. Once suitably positioned, the one or more sensors (8) sense physiological signals from the vascular tissue and bone structure.
