A) Systems and methods for bilateral treatment of a patient having a head with a first ear and a second ear function by aligning a first device with a target tissue of the first ear aligning a second device with a target tissue of the second ear and therapeutically remodeling, with synchronization, the target tissues of the first and second ear with the first and second aligned devices, respectively. B) Systems and methods for treating a patient having a head with a first ear and a second ear function by mounting a support system to the head of the patient so that the support system is aligned with a target tissue of the first ear applying a therapeutic agent to the first ear by energizing an iontophoresis electrode supported by the support system and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. C) Systems and methods for treating a patient having an ear canal and a target tissue function by positioning a fluid or gel in the ear canal, the fluid or gel comprising a therapeutic agent retaining the fluid or gel with a support structure, the support structure supporting an electrode and a battery and applying the agent from the fluid or gel to the target tissue by energizing the electrode with an iontophoresis potential from the battery. D) Systems and methods for treating a patient having a head with a first ear and a second ear, function by mounting a support structure to the head of the patient aligning the support structure with a target tissue in an ear canal of the first ear stabilizing the support structure relative to the target tissue by injecting a material into the canal and hardening the material and actuating a device while the device is supported by the support system so that the device therapeutically remodels the target tissue of the first ear. E) Systems and methods for treating a patient having a head with a first ear and a second ear, function by