PINSCHEWER, DANIEL DAVID,MERKLER, DORON,KALLERT, SANDRA MARGARETE,KREUTZFELDT, MARIO,DARBRE ABDELRAHMAN, STEPHANIE GABRIELLE,PAGE, NICOLAS JEAN
申请号：
CA2967720
公开号：
CA2967720A1
申请日:
2015.11.12
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
The present application relates to arenaviruses with rearrangements of their open reading frames ("ORF") in their genomes. In particular, described herein is a modified arenavirus genomic segment, wherein the arenavirus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented arenavirus particles comprising one L segment and two S segments or two L segments and one S segment. The arenavirus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.
