PINSCHEWER, Daniel David,MERKLER, Doron,KALLERT, Sandra Margarete,KREUTZFELDT, Mario,DARBRE ABDELRAHMAN, Stephanie Gabrielle,PAGE, Nicolas Jean
申请号：
LT15794900
公开号：
LT3218504T
申请日:
2015.11.12
申请国别(地区):
LT
年份:
2020
代理人:
摘要：
The present application relates to arenaviruses with rearrangements of their open reading frames (“ORF”) in their genomes. In particular, described herein is a modified arenavirus genomic segment, wherein the arenavirus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented arenavirus particles comprising one L segment and two S segments or two L segments and one S segment. The arenavirus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.
