Daniel David Pinschewer,Doron Merkler,Sandra Margarete Kallert,Mario Kreutzfeldt,Stéphanie Gabrielle Darbre Abdelrahman,Nicolas Jean Page
申请号：
US15526211
公开号：
US20170319673A1
申请日:
2015.11.12
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present application relates to arenaviruses with rearrangements of their open reading frames (“ORF”) in their genomes. In particular, described herein is a modified arenavirus genomic segment, wherein the arenavirus genomic segment is engineered to carry a viral ORF in a position other than the wild-type position of the ORF. Also described herein are trisegmented arenavirus particles comprising one L segment and two S segments or two L segments and one S segment. The arenavirus, described herein may be suitable for vaccines and/or treatment of diseases and/or for the use in immunotherapies.
