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CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOF
专利权人:
UNIVERSITY OF MARYLAND BALTIMORE
发明人:
WANG LAI XI,HUANG WEI
申请号:
IN6806DEN2014
公开号:
IN6806DEN2014A
申请日:
2014.08.13
申请国别(地区):
IN
年份:
2015
代理人:
摘要:
The present invention provides for recombinant Endo S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc protein acceptor. Such recombinant Endo S mutants are useful for efficient glycosylation remodeling of IgGl Fc domain to provide different antibody glycoforms carrying structurally well defined Fc N glycans.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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