CHEMOENZYMATIC GLYCOENGINEERING OF ANTIBODIES AND FC FRAGMENTS THEREOF

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专利权人:

UNIVERSITY OF MARYLAND; BALTIMORE

发明人:

LAI-XI WANG,WEI HUANG

申请号：

US15256854

公开号：

US20170058040A1

申请日:

2016.09.06

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention provides for recombinant Endo-S mutants that exhibit reduced hydrolysis activity and increased transglycosylation activity for the synthesis of glycoproteins wherein a desired sialylated oxazoline or synthetic oligosaccharide oxazoline is added to a core fucosylated or nonfucosylated GlcNAc-protein acceptor. Such recombinant Endo-S mutants are useful for efficient glycosylation remodeling of IgG1-Fc domain to provide different antibody glycoforms carrying structurally well-defined Fc N-glycans.

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