The present invention relates to a pharmaceutical composition including: a pharmaceutically effective amount of at least one peptide； and a pharmaceutically acceptable amount of a combination of: (a) at least one metal in form of any or a combination of a salt thereof and a complex thereof； and (b) at least one reducing agent, wherein, the at least one metal is selected from any or a combination of: vanadium, chromium and manganese, and wherein the combination of (a) at least one metal in form of any or a combination of a salt and a complex and (b) at least one reducing agent affords protection, at least in part, to the at least one peptide from proteolytic degradation upon ingestion thereof.本發明係關於一種藥物組合物，包含：藥學上有效劑量之至少一種胜肽；及藥學上可接受劑量之一組合，其包含(a)至少一種金屬，該金屬係呈其之任何鹽類或鹽類之組合及複合物、及(b)至少一種還原劑；其中，該至少一種金屬係任一或選自由釩、鉻及錳之組合；且，該(a)該金屬係呈其之任何鹽類或鹽類之組合及複合物之組合及(b)該至少一種還原劑之該組合，可提供對於該至少一種胜肽於攝入時，至少部分不會被蛋白質水解降解之保護。
