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polymeric systems for releasing anti-cancer agents
专利权人:
REXAHN PHARMACEUTICALS; INC.
发明人:
CHANG HO AHN,DEOG JOONG KIM,YOUNG BOK LEE
申请号:
BR112012008772
公开号:
BR112012008772A2
申请日:
2010.10.13
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
The present invention relates to compositions for the treatment of cancerous tissues in warm-blooded animals containing one or two anticancer agents attached to polymeric carriers having monomer units derived from one or more of N-(2-carboxypropyl)methacrylamide (2-CPMA), N-(3-carboxypropyl)methacrylamide (3-CPMA), N-(2-aminopropyl)methacrylamide (2-APMA) and/or N-(3-aminopropyl)methacrylamide (3-APMA) are also included. Anticancer agents in compositions can be attached to said polymeric carrier by side-chains which can be susceptible to hydrolysis by lysosomal enzymes intracellularly. Compositions can also include a targeting ligand attached to the polymeric carrier, optionally through a second linker.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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