The present invention relates to an amino 6-membered ring derivative and pharmaceutical applications thereof, which specifically relates to the amino 6-membered ring derivative represented by the general formula (I) or stereoisomers thereof, pharmaceutically acceptable salts thereof, a prodrug, a pharmaceutical composition comprising the derivative, and the pharmaceutical use for manufacturing dipeptidyl peptidase-4(IDPP-IV) inhibitor, wherein the definition of each substituent in the general formula (I) is the same as described in the specification.本發明涉及一種氨基六員環類衍生物及其在醫藥上的應用,具體而言涉及通式(I)所示的氨基六員環類衍生物或其立體異構物、藥學上可接受的鹽、前藥、含有該衍生物的醫藥組合物以及在製備二肽基肽酶IV(DPP-IV)抑制劑的醫藥上的用途,其中通式(I)中各取代基的定義與說明書的定義相同。
