WATT, DAVID S.,LIU, CHUNMING,SVIRIPA, VITALIY M.,ZHANG, WEN
申请号：
EP12739698
公开号：
EP2673250A4
申请日:
2012.01.27
申请国别(地区):
EP
年份:
2014
代理人:
摘要：
Stilbene analogs and pharmaceutical compositions that are useful for the treatment of various cancers, including without limitation, colorectal cancer (CRC) and breast cancer are disclosed. Such stilbene analogs include, for example, compounds of the following formula: wherein Ra, Rb, R4, R6, R7, R9 and R10 are all H R2 and R3 are independently H, halo, amino, alkylamino, dialkylamino, N-oxides of dialkylamino, arylalkylamino, trialkylammonium, mercapto, alkylthio, alkanoyl, nitro, nitrosyl, cyano, alkoxy, alkenyloxy, aryl, heteroaryl, sulfonyl, sulfonamide, CONR11R12, NR11CO(R13), NR11COO(R13) or NR11CONR12R13 R11, R12 and R13, are independently, H, alkyl, aryl, heteroaryl or a fluorine R8 is NRCRdZ wherein Rc is H, alkyl, alkoxy, aryl or heteroaryl, Rd is an alkyl group, Z is a an unshared pair of electrons, H, alkyl or oxygen and R1 and R5 are halogen.
