Haynes Barton,Kelsoe Garnett,Lowy Israel,Baras Aris I.,MacDonald Lynn,McWhirter John,Gurer Cagan,Meagher Karolina A.,Murphy Andrew J.,Yancopoulos George D.
申请号：
US201414174563
公开号：
US9963501(B2)
申请日:
2014.02.06
申请国别(地区):
美国
年份:
2018
代理人:
Choi Yongjin`Alston & Bird LLP
摘要：
Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-lineage immunogen design in vaccine development are provided, as are methods of carrying out such design.
