Barton Haynes,Garnett Kelsoe,Israel Lowy,Aris I. Baras,Lynn MacDonald,John McWhirter,Cagan Gurer,Karolina A. Meagher,Andrew J. Murphy,George D. Yancopoulos
申请号：
US14174563
公开号：
US09963501B2
申请日:
2014.02.06
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Non-human animals with humanized immunoglobulin loci and methods of using them in vaccine design are described, as well as methods for making broadly neutralizing antibodies against infectious agents and pathogens are provided. Non-human animals with humanized immunoglobulin loci used in B-cell-lineage immunogen design in vaccine development are provided, as are methods of carrying out such design.
