INDAZOLE AND INDOLE DERIVATIVES AS INHIBITORS OF RETINOIC ACID RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA) FOR THE TREATMENT OF IMMUNE-RELATED DISEASES

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专利权人:

ORCA PHARMACEUTICALS LIMITED

发明人:

CLIVE MCCARTHY,NAOMI WENT,ROINE INGE OLSSON

申请号：

US16539143

公开号：

US20200030290A1

申请日:

2019.08.13

申请国别(地区):

US

年份:

2020

代理人:

摘要：

The present invention provides compounds of formula (I), wherein A1, A2, Z1, Z2, Z3, R1, R2, R3, R4, R5, R6, n, p and q are as defined herein. In certain embodiments, the compounds of the invention are RORγt antagonists. In other embodiments, the compounds of the invention are useful in the treatment and/or prevention of inflammatory and autoimmune conditions.

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