#$%^&*AU2018226377A120180927.pdf#####The invention relates to storage-stable compositions comprising a silk fibroin matrix and an active agent distributed therein, wherein the active agent retains at least about 30% of its original bioactivity when the composition is subjected to at least one state-changing cycle, and/or is maintained for a period of time under a specified condition. In some embodiments the active agent is a vaccine, the state-changing cycle is a freeze-thaw cycle, the period of time for maintaining the active agent is at least about 24 hours, and the specified condition can be an environmental condition under which an active agent is stored and/or transported. The invention also relates to kits and delivery devices, e.g., useful in biomedical fields, utilising the above-mentioned compositions.WO 2012/145739 PCT/US2012/034643 12/22 I I AMI ivni % M1dICI3 CCIA L JI -- ---- -%)AON31Od IVOOISIH (%) A3N3IOd 1VOWIS]N
