The present invention relates to novel Phosphodiesterase type 4 (PDE4) inhibitors of the formula (1) and analogs, tautomers, enantiomers, diasteromers, regioisomers, stereoisomers, polymorphs, pharmaceutically acceptable salts, appropriate N-oxides, pharmaceutically acceptable solvates thereof and the pharmaceutical compositions containing them which are useful in the treatment of allergic and inflammatory diseases including asthma, chronic bronchitis, atopic dermatitis, urticaria, allergic rhinitis, allergic conjunctivitis, vernal conjuctivitis, eosinophilic granuloma, psoriasis, rheumatoid arthritis, septic shock, ulcerative colitis, Crohn's disease, reperfusion injury of the myocardium and reperfusion injury of the brain, chronic glomerulonephritis, endotoxic shock and adult respiratory distress syndrome.本發明是有關新穎的具有化學式(1)之第4型磷酸二酯酶(PDE4)抑制劑；及其類似物、互變異構物、鏡像異構物、非鏡像異構物、區域異構物(regioisomer)、立體異構物、多形物、藥學上可接受的鹽類、合適的N－氧化物、藥學上可接受的溶劑合物，以及包含它們的藥學組成物，該藥學組成物可用於治療過敏性與發炎性疾病，包含氣喘、慢性支氣管炎、異位性皮膚炎、蕁麻疹、過敏性鼻炎、過敏性結膜炎、春季結膜炎、嗜伊紅細胞性肉芽腫、牛皮癬、風濕性關節炎、敗血性休克、潰瘍性結腸炎、克隆氏症、心肌的再灌注損害以及腦的再灌注損害與、慢性腎絲球性腎炎、內毒素性休克以及成人呼吸困難徵候群。
