FIELD: pharmaceutics.SUBSTANCE: invention relates to spirocyclic amine derivatives of formula (I), where R1 is selected from cyano, (2-4C)alkenyl, (2-4C)alkynyl, (1-4C)alkyl, each of which is optionally substituted with CN or one or more fluorine atoms, (3-6C)cycloalkyl, (4-6C)cycloalkenyl or (8-10C)bicyclic group, where each of said groups is optionally substituted with halogen or (1-4C)alkyl, phenyl, optionally substituted with one or more substitutes, independently selected from halogen, (1-6C)alkyl, optionally substituted with one or more fluorine atoms, (1-6C)alkoxy, optionally substituted with one or more fluorine atoms, and (3-6C)cycloalkyl, optionally substituted with phenyl； biphenyl, optionally substituted with halogen； naphthyl； phenyl, substituted with monocyclic heterocycle； Monocyclic heterocycle, optionally independently substituted with halogen, (1-6C)alkyl, optionally substituted with one or more fluorine atoms, (3-6C)cycloalkyl or phenyl, optionally substituted (1-4C)alkyl or halogen, and bicyclic heterocycle, optionally substituted with halogen or (1-4C)alkyl, optionally substituted with one or more fluorine atoms； -Y-(Cn-alkylene)-X- is a binding group, where Y is bonded to R1 and is selected from a bond, -O-, -CO-, -S-, -SO-, -SO2-, -CH=CH-, -C(CF3)=CH-, -C≡C-, -CH2-O-, -CO-NH-, -NH-CO- and trans-cyclopropylene； n is an integer between 0 and 10； and X is bonded to a phenylene group and is selected from a bond -O-, -S-, -SO-, -SO2-, -NH-, -CO-, -CH=CH- and trans-cyclopropylene； R2 is H or is independently selected from one or more substitutes selected from halogen, (1-4C)alkyl, optionally substituted with one or more fluorine atoms； R3 is (1-4C)alkylene-R4, where alkylene group can be substituted with one or more halogen atoms or (CH2)2 to form by a cyclopropyl group, or R3 is (3-6C)cycloalkylene-R4, or -CO-CH2-R4, where R4 is -OH, -PO3H2, -OPO3H2, -COOH, -COO(1-4C)alkyl or tetrazol-5-yl； Q is a bond； -W-T- is selected from -CH=CH-, -CH2-CH2-, -C
