The present invention relates to a fused heterocyclic derivative of the formula (I)wherein R1 is selected from cyano, (2-4C)alkenyl, (2-4C)alkynyl, (1 .-4C)alkyl, each optionally substituted with CN or one or more fluoro atoms, (3-6C)cycloalkyl, (4-6C)cycloalkenyl or a (8.10C)bicyclic group, each optionally substituted with halogen or (1-4C)alkyl optionally substituted with one or more fluoro atoms, phenyl, biphenyl, naphthyl, each optionally substituted with one or more substi.tuents independently selected from halogen, cyano, (1-4C)alkyl optionally substituted with one or more fluoro atoms, (1-4C)alkoxy optionally substituted with one or more fluoro atoms, amino, dimethylamino, and (3-6C)cycloalkyl optionally substituted with phenyl which may be substituted with (1-4C)alkyl or halogen, and phenyl substituted with phenoxy, benzyl, benzyloxy, phenylethyl or monocyclic heterocycle, each optionally substituted with (1-4C)alkyl, Z is a linking group-W-(C,,-alkylene)-T-wherein W is attached to R1 and selected from a bond, -0-, -CO-, -S-, -SO-, -SO2-, -NH-CH=CH-, -C(CF3)=CH-, -C=C-, -CH2-0-, -O-CO-, -CO-O-, -CO-NH-NH-CO- and trans-cyclopropylene； n is an integer from 0 to 10； and T is attached to the phenylenelpyrid.yl moiety and selected from a bond, -0-, -S, -SO-, -SO2-, -NH-, -CO-, -C=C-, -CaC-, and trans-cyclopropylene； R2 is H or one or more substituents independently selected from cyano, halogen, (1-4C)alkyl optionally substituted with one or more halogen atoms, or (1-4C)alkoxy optionally substituted with one or more halogen atoms； ring structure A may contain one nitrogen atom； X is selected from C or N； if X is C, R3 is selected from H and (1-4C)alkyl, otherwise R3 is not present； Y is selected from NH, 0 and S； structure Q is a 5-, 6- or 7- membered cyclic amine； and R4 is (1-4C)alkylene-R5 wherein one or more carbon atoms in the alkylene group may independently be substituted with one or more halogen atoms or with (CH2)2 to form a cyclopropyl moiety , or R4 is
