A mobile base designed to receive an X-ray machine is provided. An X-ray machine capable of being mounted on the mobile base is also provided. The X-ray machine of the invention is configured to move using a motor-driven system associated with a navigation system. The navigation system of the invention enables the X-ray machine to be moved automatically and with precision from one position to another within an examination, hybrid or operation room. The X-ray machine is also configured for the automatic positioning of the moving parts around the patient, while at the same time keeping the region to be subjected to radiography within an X-ray beam