YEN, SHIH CHIEH,严士杰,嚴士傑,LIAO, CHU BIN,廖助彬,WANG, HUI CHEN,王慧贞,王慧貞,CHEN, PO TING,陈柏廷,陳柏廷,PAN, YU CHIH,潘语之,潘語之,LI, TSUNG HUI,李从慧,李從慧,CHEN, BO RONG,陈柏蓉,陳柏蓉,CHIOU, SHIAN YI,邱显益,邱顯益
申请号：
TW107147559
公开号：
TW201930306A
申请日:
2018.12.28
申请国别(地区):
TW
年份:
2019
代理人:
摘要：
Disclosed are compounds of formula (I) below and tautomers, stereoisomers, isotopologues, or pharmaceutically acceptable salts thereof: in which each of variables R1, ring A, L, W, V, and G is defined herein. Also disclosed are a method for treating disease or disorder mediated by Tyro3, Axl, and/or Mer kinase with a compound of formula (I) or a tautomer, stereoisomer, isotopologue, or salt thereof and a pharmaceutical composition containing same.本發明係為具有式(I)之化合物結構，以及式(I)所示化合物的互變異構物、立體異構物、同位素異構物和藥學可接受的鹽類： 其中，R1、環A、L、W、V和G定義於說明書中。本發明另公開用式(I)所示化合物，或式(I)所示化合物的互變異構物、立體異構物、同位素異構物和藥學可接受的鹽類，用於治療由Tyro3、Axl和/或Mer激酶介導之疾病或失調的方法。
