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Mean DNA copy number of chromosomal regions is of prognostic significance in cancer
专利权人:
North Carolina State University
发明人:
Breen Matthew
申请号:
US201013515614
公开号:
US9090945(B2)
申请日:
2010.12.14
申请国别(地区):
美国
年份:
2015
代理人:
Jenkins, Wilson, Taylor & Hunt, P.A.
摘要:
Methods for predicting a disease free time interval (DFI) for a cancer patient under consideration for initial or further chemotherapy treatment are disclosed. The methods include obtaining a biological sample from a patient and detecting a copy number of chromosome region A1 and/or C2. The mean copy number per cell is correlated with a DFI for the subject. The chemotherapy can include doxorubicin and/or L-asparaginase treatment. Also provided are kits for predicting DFI in a subject with cancer and computer readable storage media for performing the presently disclosed methods.
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