Metoda za pripravo 1-(4-(4-(3,4-dikloro-2-fluorofenilamino)-7-metoksikinazolin-6-iloksi) piperidin-1-IL)-PROP-2-EN-1-ON hidroklorida in intermediati uporabljeni pri tem
- 专利权人:
- Hanmi Science Co.; Ltd.
- 发明人:
- BANG Keuk Chan,MOON Young Ho,CHANG Young Kil
- 申请号：
- SI201231742
- 公开号：
- SI2763981T1
- 申请日:
- 2012.10.05
- 申请国别(地区):
- SI
- 年份:
- 2020
- 代理人:
- 摘要：
- The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase.
- 来源网站：
- 中国工程科技知识中心
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