MÉTODO DE PREPARAÇÃO DE CLORIDRATO DE 1-(4-(4-(3,4-DICLORO-2-FLUOROFENILAMINO)-7-METOXIQUINAZOLIN-6-ILOXI)PIPERIDIN-1-IL)-PROP-2-EN-1-ONA E INTERMEDIÁRIOS UTILIZADOS NO MESMO

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专利权人:

LTD.;HANMI SCIENCE CO.

发明人:

申请号：

PT12838558

公开号：

PT2763981T

申请日:

2012.10.05

申请国别(地区):

PT

年份:

2020

代理人:

摘要：

The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/