Sposób wytwarzania chlorowodorku 1-(4-(4-(3,4-dichloro-2-fluorofenyloamino)-7-meto-ksychinazolin-6-yloksy)piperydyn-1-ylo)prop-2-en-1-onu i stosowane w nim związki pośrednie
The present invention relates to an improved method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-prop-2-en-1-one, which selectively and effectively inhibits the growth of cancer cells induced by over-expression of an epidermal growth factor receptor (EGFR) and prevents the development of drug resistance caused by mutation of a tyrosine kinase.
