This invention, when the medicine, the absorption accelerator and the plasticizer etc are contained mainly, is superior even in adhesion quality such as cohesion power, when the medicine is included, stickiness matrix layer, the adhesion base which consists of the polymer which possesses hydroxyl group, contains the boron compound and silica in the external use medicine which includes stickiness matrix layer in regard to the external use medicine which is superior in dermal absorptivity, the aforementioned external use medicine is offered.本発明は、薬物、吸収促進剤、可塑剤などを多く含有する場合であっても、凝集力などの粘着特性にも優れ、薬物を含む場合には、経皮吸収性に優れる外用剤に関し、粘着性マトリクス層を含む外用剤において、粘着性マトリクス層が、水酸基を有する重合体からなる粘着基剤、ホウ素化合物、ケイ酸を含有する、前記外用剤を提供する。
