BAHMANYAR, Sogole,BATES, R.J.,BLEASE, Kate,CALABRESE, Andrew Antony,DANIEL, Thomas Oran,DELGADO, Mercedes,ELSNER, Jan,ERDMAN, Paul,FAHR, Bruce,FERGUSON, Gregory,LEE, Branden,NADOLNY, Lisa,PACKARD, Gar
申请号：
ES09789271
公开号：
ES2581565T3
申请日:
2009.09.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt, tautomer, stereoisomer or solvate thereof, wherein: R1 is a substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclyl； R2 is a substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl alkyl, a substituted or unsubstituted aralkyl, -OR3, -C (>； = O) R5, -C (>； = O) NR3R4, -NHC (>； = O) R3, - (CH2) 0-2CR6 (OR3) R4 or a substituted or unsubstituted heterocyclyl selected from 1,2,3,6-tetrahydropyridyl, bencisoxazolyl or isoindolin-1-onyl . R3 and R4 are each time independently -H, a substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl substitute, a substituted or unsubstituted aralkyl or a substituted or unsubstituted heterocyclylalkyl； R5 is substituted or unsubstituted C1-8 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocyclyl, a substituted or unsubstituted aralkyl or a substituted heterocyclyl alkyl or without replacing； and R6 is -H, or a substituted or unsubstituted C1-8 alkyl, or together with R4 and the atoms to which they are attached form a substituted or unsubstituted heterocyclyl.Un compuesto de fórmula (I):**Fórmula** o una sal, tautómero, estereoisómero o solvato farmacéuticamente aceptable del mismo, en donde: 5 R1 es un arilo sustituido o sin sustituir o un heterociclilo sustituido o sin sustituir； R2 es un alquilo C1-8 sustituido o sin sustituir, un cicloalquilo sustituido o sin sustituir, un heterociclilalquilo sustituido o sin sustituir, un aralquilo sustituido o sin sustituir, -OR3, -C(>；=O)R5, -C(>；=O)NR3R4, -NHC(>；=O)R3, - (CH2)0-2CR6(OR3)R4 o un heterociclilo sustituido o sin sustituir seleccion
