A compound of formula I: wherein: R 1 is selected from halogen, C 1-6 alkyl, C 3-12 cycloalkyl, C 3-8 heterocycloalkyl, C 6-10 aryl and C 3-10 heteroaryl； wherein said C1-6 alkyl of R1 is optionally substituted with 1 to 3 radicals independently selected from halogen, hydroxyl, cyano, nitro,>； = N (OH), C14 alkoxy and benzoxyl； wherein said cycloalkyl, heterocycloalkyl, aryl or heteroaryl of R1 is optionally substituted with 1 to 3 independently selected radicals of halogen, hydroxyl, cyano, nitro, C1-6 alkyl, C1-6 alkyl halogen, C1-6 alkyl hydroxyl substituted, C1 alkoxy -6, halogenated C1-6 alkoxy substituted, -X1NR3aR3b, -X1C (O) R3a, -X1C (O) OR3a, -X1OR3a, C3-12 cycloalkyl, C3-8 heterocycloalkyl, C6-10 aryl and C3-10 heteroaryl； wherein X1 is selected from a bond and C1-4 alkylene； in which R3a and R3b are independently selected from hydrogen and C1-6 alkyl； R2 is selected from methyl and ethyl； A is an unsaturated member ring containing 2 or 3 heteroatoms or groups selected from>； = N-, -NR4-, -O- and -S (O) 0-2-； wherein R4 is selected from hydrogen, C1-4 alkyl and C3-8 cycloalkyl； wherein said C1-4 C3-8 alkylcycloalkyl of R4 may have a methylene replaced by a heteroatom selected from O, S (O) 0-2 and NR30； wherein R30 is selected from hydrogen and C1-4 alkyl； in which A may be optionally substituted with C1-2 alkyl； or pharmaceutically acceptable salts and solvates thereof.Un compuesto de fórmula I:en la que:R1 se selecciona de halógeno, alquilo C1-6, cicloalquilo C3-12, heterocicloalquilo C3-8, arilo C6-10 y heteroarilo C3-10； enlos que dicho alquilo C1-6 de R1 está opcionalmente sustituido con 1 a 3 radicales independientemente seleccionadosde halógeno, hidroxilo, ciano, nitro, >；= N(OH), alcoxilo C14 y benzoxilo； en los que dicho cicloalquilo, heterocicloalquilo,arilo o heteroarilo de R1 está opcionalmente sustituido con 1 a 3 radicales independientemente seleccionados dehalógeno, hidroxilo, ciano, nitro, alquilo C1-6, alquilo C1-6 halogenosustituid
