A determination processing unit determines a disease region in a medical image including an axisymmetric structure. A first determination section of the determination processing unit generates a feature amount map of the medical image from the medical image. A second determination section second inverts the feature amount map with reference to a symmetry axis to generate an inverted feature amount map. A third determination section superimposes the feature amount map and the inverted feature amount map on each other and determines the disease region in the medical image using the feature amount map and the inverted feature amount map superimposed on each other.