David PIWNICA-WORMS,Adnan ELHAMMALI,Joseph E. IPPOLITO,Seth GAMMON
申请号：
US14669700
公开号：
US20150273088A1
申请日:
2015.03.26
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Zaprinast has been discovered to have activity against glutaminase 1, an important metabolic enzyme in selected cancers, for example, glutamine-dependent cancer types. Thus, glutamine-dependent cancer types, such as IDH1/2 gain-of-function mutant cancers or GLI1 overexpressing cancers, may be particularly sensitive to Zaprinast analogues.
