ANTAGONISTES COMBINES DIRIGES CONTRE IL-5/IL-5R ET SOIT IL-4/IL-4R, SOIT IL-13/IL-13R

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专利权人:

ARGENX BVBA

发明人:

BLANCHETOT, CHRISTOPHE,GODAR, MARIE,LAMBRECHT, BART

申请号：

CA3088734

公开号：

CA3088734A1

申请日:

2019.02.15

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

The present invention relates to combination therapies and to their use in the treatment of chronic airway disease, particularly use in the treatment of asthma. The combination therapies comprise (i) an antagonist of IL-5:IL-5R and (ii) an antagonist of IL-4:IL-4R and/or an antagonist of IL-13:IL-13R. The present invention also provides bispecific antibodies comprising an antigen binding domain that binds to IL-4Ra and an antigen binding domain that binds to IL-5. The bispecific antibodies may be used for the treatment of chronic airway disease, particularly asthma.

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