LIGANDS ET RADIOLIGANDS HAUTEMENT SELECTIFS DU RECEPTEUR SIGMA SERVANT DE SONDES DANS LE TRAITEMENT NOCICEPTIF ET L'ETUDE PATHOPHYSIOLOGIQUE DE DEFICIENCES DE LA MEMOIRE ET DE TROUBLES COGNITIFS
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;THE UNIVERSITY OF MISSISSIPPI
发明人:
MCCURDY, CHRISTOPHER R.,MESANGEAU, CHRISTOPHE,CHIN, FREDERICK T.,JAMES, MICHELLE L.,SHEN, BIN,GAMBHIR, SANJIV,BISWAL, SANDIP,BEHERA, DEEPAK
申请号：
CA2941634
公开号：
CA2941634A1
申请日:
2015.03.03
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Compounds having the general formula III′, or IV′wherein R1 can be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: R2,4,5,6 can each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium； Y is S； Z can be either H, O, S, S—R or NR where R groups can be either H, aryls, alkyls, or cycloalkyls； “n” can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging R1 and N can be a substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C3-C5 cycloalkyl group, aromatic, and heterocyclic group； and wherein X is C1-C4 radiohaloalkyl.
