PROBLEM TO BE SOLVED: To provide a compound having μ-opioid receptor antagonism which has few side effects and high safety.SOLUTION: There is provided a compound represented by the formula (I) or a pharmacologically acceptable salt thereof. [R1 and R2 represent H or a halogen atom R3 represents a C1-3 alkyl or vinyl and R4 represents OH, a C1-C3 alkoxy-substituted indan, a C1-C3 alkoxy-substituted/a nonhalogenated C5-C7 cycloalkyl ethyl or a halogenated 5 to 7 membered saturated hetero ring-substituted ethyl.]SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT【課題】副作用の少ない、安全性の高いμオピオイド受容体拮抗作用を有する化合物の提供。【解決手段】式(I)で表される化合物又はその薬理上許容される塩。[R1及びR2はH又はハロゲン;R3はC1-3アルキル又はビニル;R4はOH又はC1-C3アルコキシ置換インダン、C1-C3アルコキシ置換/非置換ハロゲン化C5-C7シクロアルキルエチル又はハロゲン化5-7員飽和ヘテロ環置換エチル]【選択図】なし
