Optically active novel intermediates that can be produced with good yield and economical short steps tetrahydropyrrolo of ranirestat or the like which is expected to serve as agents for treating diabetic complications [1,2-a] pyrazine-4-spiro-3-pyrrolidine derivatives formula is (III): (Wherein, R., Which means a C 1-6 alkyl group) compound represented by the formula and method of manufacturing the same.糖尿病合併症治療薬として期待されるラニレスタット等のテトラヒドロピロロ[1,2-a]ピラジン-4-スピロ-3’-ピロリジン誘導体を短工程で経済的かつ収率よく製造できる新規な光学活性中間体である式(III):(式中、RはC1-6アルキル基を意味する。)で表される化合物およびその製造方法。
