Melanie Tellers;Bret A Shirley;Maninder Hora;Susan Babuka;Bao-Lu Chen;Minna Choe
发明人:
Bret A Shirley,Susan Babuka,Bao-Lu Chen,Maninder Hora,Minna Choe,Melanie Tellers
申请号：
US13004658
公开号：
US08333958B2
申请日:
2011.01.11
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
