HSA-FREE INTERFERON-BETA FORMULATIONS

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专利权人:

NOVARTIS VACCINES AND DIAGNOSTICS; INC.

发明人:

SHIRLEY, BRET,CHOE, MINNA,TELLERS, MELANIE,BABUKA, SUSAN,CHEN, BAO-LU,HORA, MANINDER

申请号：

AT01988466

公开号：

AT545430T

申请日:

2001.10.26

申请国别(地区):

AT

年份:

2012

代理人:

摘要：

Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-²) and methods useful in their preparation are provided. The compositions comprise the IFN-² solubilised in a low-ionic-strength formulation that maintains the composition at a pH of about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-² in pharmaceutical compositions, are provided.

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