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MODULATEURS DU RECEPTEUR NICOTINIQUE DE L'ACETYLCHOLINE
- 专利权人:
- ASTRAEA THERAPEUTICS; LLC
- 发明人:
- ZAVERI, NURULAIN T.,JIANG, FAMING,TOLL, LAWRENCE
- 申请号：
- CA2787063
- 公开号：
- CA2787063C
- 申请日:
- 2011.01.11
- 申请国别(地区):
- CA
- 年份:
- 2018
- 代理人:
- 摘要：
- Provided herein are selective high affinity .alpha.3.beta.4 nicotinicacetycholine receptorligands of formula (I):or salts, hydrates or solvates thereof wherein: R1 is hydrogen, alkanyl,substituted alkanyl,cycloalkanyl, substituted cycloalkanyl, alkenyl, substituted alkenyl,cycloalkenyl, substitutedcycloalkenyl, alkynl, substituted alkynl, heteroalkanyl, substitutedheteroalkanyl,heterocycloalkanyl, substituted heterocycloalkanyl, heteroalkenyl, substitutedheteroalkenyl,heterocycloalkenyl, substituted heterocycloalkenyl, heteroalkynyl, substitutedheteroalkynyl,arylalkanyl, substituted arylalkanyl, arylcycloalkanyl substitutedarylcycloalkanyl,arylalkenyl, substituted arylalkenyl, arylcycloalkenyl, substitutedarylcycloalkenyl,arylalkynyl, substituted arylalkynyl, heteroarylalkanyl, substituted heteroarylalkanyl,heteroarylcycloalkanyl substituted heteroarylcycloalkanyl, heteroarylalkenyl,substitutedheteroarylalkenyl, heteroarylcycloalkenyl, substituted heteroarylcycloalkenyl,heteroarylalkynyl, substituted heteroarylalkynyl, or -CO2R2； R2 is alkanyl,substitutedalkanyl, cycloalkanyl, substituted cycloalkanyl, alkenyl, substituted alkenyl,cycloalkenyl,substituted cycloalkenyl, alkynl, substituted alkynl, heteroalkanyl,substituted heteroalkanyl,heterocycloalkanyl, substituted heterocycloalkanyl, heteroalkenyl, substitutedheteroalkenyl,heterocycloalkenyl, substituted heterocycloalkenyl, heteroalkynyl, substitutedheteroalkynyl,arylalkanyl, substituted arylalkanyl, arylcycloalkanyl substitutedarylcycloalkanyl,arylalkenyl, substituted arylalkenyl, arylcycloalkenyl, substitutedarylcycloalkenyl,arylalkynyl, substituted arylalkynyl, heteroarylalkanyl, substituted heteroarylalkanyl,heteroarylcycloalkanyl substituted heteroarylcycloalkanyl, heteroarylalkenyl,substitutedheteroarylalkenyl, heteroarylcycloalkenyl, substituted heteroarylcycloalkenyl,heteroarylalkynyl, substituted heteroarylalkynyl；
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
