Wenge Zhong,Stephen Hitchcock,Vinod F. Patel,Michael Croghan,Thomas Dineen,Scott Harried,Daniel Horne,Ted Judd,Matthew Kaller,Charles Kreiman,Patricia Lopez,Holger Monenschein,Thomas Nguyen,Matthew We
申请号：
US12154513
公开号：
US08163909B2
申请日:
2008.05.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimers disease (AD) and related conditions. In one embodiment, the compounds have a general Formula Ior Formula IIwherein R1a, R1b, R1c, B, R3, R4, R5 and W of Formula I, and R1a, R1b, R1c, R2, R2a, R3, R4, R5, A1, A2, A3, A4, W, X, Z, m and n of Formula II are defined herein. The invention also provides compounds of Formula III, sub-Formulas II-A-II-D, sub-Formulas III-A-III-D and Formula IV. The invention further includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, AD, cognitive deficits and impairment, schizophrenia and other similar central nervous system conditions. The invention also comprises further embodiments of Formulas I, II, III, IV and sub-formulas thereof, intermediates and processes useful for the preparation of compounds of Formulas I, II, III, IV and sub-formulas thereof.
