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Subsituted sulphonamides, process for their preparation, pharmaceutical composition comprising thereof and their use
专利权人:
UNIMED PHARMA; spol. s r.o.
发明人:
Remko, Milan,Knapikova, Jarmila,Gregan, Fridrich,Sluciakova, Elena
申请号:
AU2008241590
公开号:
AU2008241590B2
申请日:
2008.04.18
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
Substituted sulphonamides having the general formula (I) and salts, hydratesand solvates thereof were prepared and described, wherein R isCOor SO and R is NH or O and where R represents linear or cyclicaliphatic chain and n represents number of linking aliphatic chain carbons (ncan be 0, 1, 2 or 3), which are useful in the manufacture of the medicaments due tothe carboanhydrase inhibition. These compounds are prepared by nucleophilicreaction of an amine with 4-sulfamoylbenzenesulphonyl chloride in the presenceof triethylamine excess in tetrahydrofurane or in ether at temperature 0 to 20°C. The compounds show an antiglaucomatic activity.
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